Hipa test
Synonym(s)
Heparin-induced platelet activation; Heparin-induced platelet aggregation
DefinitionThis section has been translated automatically.
Detection of platelet activation in the presence of heparin or heparin derivatives.
IndicationThis section has been translated automatically.
ImplementationThis section has been translated automatically.
Incubation of platelets from healthy donors in a microtiter plate with the serum to be tested and with heparin. Platelet activation leads to sedimentation of the thrombocytes, optical measurement is used to detect the antigen-autoantibody complex.
Note(s)This section has been translated automatically.
At the same time, the test also allows a statement to be made in vitro about the compatibility of alternative preparations.
LiteratureThis section has been translated automatically.
- Greinacher A et al (1991) A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia. Thromb haemost 66: 734-736
- Greinacher A, Juhl D, Strobel U, Wessel A, Lubenow N, Selleng K, Eichler P, Warkentin TE (2007) Heparin-induced thrombocytopenia: a prospective study on the incidence, platelet-activating capacity and clinical significance of antiplatelet factor 4/heparin antibodies of the IgG, IgM, and IgA classes. J Thromb Haemost 5: 1666-1673
- Warkentin TE (2007) Heparin-induced thrombocytopenia. Hematol Oncol Clin North Am 21: 589-607
- Warkentin TE, Mason BT, Aster RH (2007) Heparin-induced thrombocytopenia associated with fondaparinux. N Engl J Med 356: 2653-2655