Herpes simplex vegetans B00.8

Herpes simplex manifestation (mostly in the area of the skin-mucosal transition zone) with ulcerous disintegration of the blisters without self-healing tendency. Mostly in cases of immunosuppression (see also Herpes simplex recidivans) - e.g. in HIV infection, in long-term immunosuppressive treated autoimmune diseases and others. If the disease persists for a longer period of time, crusty, hyperkeratotic vegetation may develop, so that the "typical" clinical link to a herpes simplex infection is lost.

In addition to the skin and mucous membranes, the lungs, liver and eyes can be affected. Herpes encephalitis, which is associated with a high mortality rate, is also a complicating organ attack in this constellation.

1. Marchalik R et al (2015) Pemphigus vegetans with coexistent herpes simplex infection and deep venous thrombosis of the lower extremities. BMJ Case Rep doi:10.1136/bcr-2015-210143.

2. Patel AB et al (2008) Herpes vegetans as a sign of HIV infection. Dermatol OnlineJ 14:6

3. Römer A et al.(2008) Herpes simplex vegetans: atypicalgenital herpes infection with prominent plasma cell infiltration in B-cellchronic lymphocytic leukemia. J Dtsch Dermatol Ges 6: 865-867.
4. Koushk-Jalali B. et al (2019) Herpes simplex vegetans in a patient with primary myelofibrosis. Infection, doi:10.1007/s15010-019-01329-y.