Granuloma gangraenescens nasi - Altmeyers Encyclopedia

Synonym(s)

extranodal NK/T-cell lymphoma; Granuloma malignant of the nose; Granulomatosis rhinogenic; Lethal midline granuloma of the face; malignant granuloma of the nose; Midline lethal granuloma; nasal and nasal type

History
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Mc Bride, 1897; Stewart, 1933

Definition
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The term has only historical meaning and describes a clinical picture that is now known as extranodal NK/T-cell lymphoma, nasal type. Clinically impressive is a chronic, severe, necrotizing inflammation in the area of the nose and middle of the face; this has since led to the term "Lethal midline granuloma of the face".

S.u. lymphoma cutaneous NK/T-cell lymphoma extranodal nasal type

Differential diagnosis
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Lupus vulgaris; rhinoscleroma; syphilis III; pyoderma; noma; malignant lymphomas; Wegener's granulomatosis.

Literature
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McBride P (1897) Photographs of a case of rapid destruction of the nose and face. J Laryngol Otol 12: 64-66
Russell-Jones R (2003) World Health Organization classification of hematopoietic and lymphoid tissues: implications for dermatology. J Am Acad Dermatol 48: 93-102
Santucci M et al (2003) Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force Workshop. Cancer 97: 610-627
Stewart JP (1933) Progressive lethal granulomatous ulceration of the nose. J Laryngol Otol 48: 657-701