DefinitionThis section has been translated automatically.
Gp130 is an important 130kDa glycoprotein that acts as a receptor for some cytokines. These cytokines include interleukin-6, interleukin-11, etc. Gp 130 was initially described as an "interleukin-6 transducer chain" or "interleukin-6 signal transducer"; the number 130 stands for its molecular mass of 130 kDa.
The glycoprotein is encoded by a gene located on chromosome section 5q11.
Together with gp130, the activating cytokines stimulate target genes involved in cell differentiation, survival, apoptosis and proliferation.
Prof. Dr. med. Peter Altmeyer