Gold preparations
DefinitionThis section has been translated automatically.
Antirheumatic drugs, basic therapeutics. For example, auranofin, sodium aurothiomalate.
IndicationThis section has been translated automatically.
Psoriatic arthritis, rheumatoid arthritis.
Notice! Before starting therapy, pregnancy must be ruled out and effective contraception must be carried out during therapy!
Limited indicationThis section has been translated automatically.
Insulin-dependent diabetes mellitus, sun exposure (including artificial UV radiation).
Undesirable effectsThis section has been translated automatically.
See Table 1.
InteractionsThis section has been translated automatically.
See Table 2.
ContraindicationThis section has been translated automatically.
Pregnancy, lactation, agranulocytosis, atopic diathesis, autoimmune diseases (dermatomyositis, systemic lupus erythematosus, scleroderma), haematopoietic disorders, bleeding tendency, ulcerative colitis, severe liver and kidney dysfunction, thrombocytopenia, active pulmonary tuberculosis, hypersensitivity to heavy metals.
TablesThis section has been translated automatically.
Side effects of gold preparations
Airways |
allergic alveolitis, bronchiolitis, interstitial pulmonary fibrosis (under therapy 1 time/year X-ray control of the thorax!) |
blood, lymph |
Agranulocytosis, hypo- to aplastic or hemolytic anemia, Eosinophilia (therapy discontinuation in > 12%) Leukopenia, neutropenia, thrombocytopenia (discontinuation of therapy if < 100,000 platelets/μl), pancytopenia, thrombocytopenic purpura |
GIT |
Loss of appetite, vomiting, diarrhea Cholestasis, jaundice, hepatitis Gastrointestinal bleeding Transaminase elevations, rarely hepatic necrosis |
Urinary tract |
Albuminuria, hematuria, proteinuria (discontinuation of therapy at > 300 mg protein/l urine), cylindruria Glomerulonephritis, immune complex nephritis gold nephropathy, tubular necrosis acute renal failure |
Skin |
allergic exanthema, pityriasis rosea-like reactions, pruritus, alopecia, Quincke's edema, anaphylactic shock, Lyell's syndrome gingivitis, stomatitis Photosensitization gray-blue pigmentation, especially in light-exposed areas intradermal gold deposits drug-induced lupus erythematosus onycholysis, hyperhidrosis |
Cardiovascular |
bradycardia, tachyarrhythmia |
Nervous system |
EEG changes, headache, seizures, hallucinations, confusional states Encephalopathy, encephalitis, neuropathy, neuritis Guillain-Barré syndrome |
Sensory organs |
metallic taste Chrysiasis (gold deposits in eye tissue) corneal ulcers iritis, conjunctivitis, neuritis optic nerves |
supporting apparatus |
Arthralgias Pain at the injection site in case of i.m. application Application |
Significant interactions of gold preparations
Butazone |
Reciprocal toxicity ↑, avoid combination. |
Chloroquine |
Retinopathy risk ↑. |
Clozapine |
Agranulocytosis, avoid combination |
Iron |
Gold effect with oral administration ↓ |
Metamizole |
reciprocal toxicity ↑, avoid combination |
NSAIDS |
Blood formation disorders, mutual toxicity ↑. |
Penicillamine |
Blood formation disorders, kidney damage, gold effect ↓, avoid combination |
Cytostatics |
mutual toxicity ↑, avoid combination |