Gold dermatitisL27.04
DefinitionThis section has been translated automatically.
Non-specific dermatitis as a side effect of gold therapy (chrysotherapy) in rheumatoid arthritis or other diseases. Incidence up to 53% of patients treated with gold. These are dose-dependent toxic changes which, in contrast to chryssiasis, are reversible.
Clinical featuresThis section has been translated automatically.
Maculopapular, erythematosquamous, lichenoid, vesicular or urticarial skin changes. Often severe pruritus.
TherapyThis section has been translated automatically.
If the skin symptoms are less severe, an interruption of the therapy or, if possible, a reduction in dose can significantly improve the skin appearance and pruritus. Only in severe cases it is necessary to remove the gold. Exanthema can persist for months even after discontinuation of therapy. In these cases long-term systemic therapy with glucocorticoids such as prednisolone (e.g. Decortin H) in medium dosages: 20-50 mg/day.
External therapyThis section has been translated automatically.
Blande local therapy e.g. with Lotio alba aq. or weakly effective glucocorticoid-containing topical preparations such as 1% hydrocortisone cream R121 R120.
LiteratureThis section has been translated automatically.
- Eisler R (2003) Chrysotherapy: a synoptic review. Inflamm Res 52: 487-501
- Fritsch P et al (1996) Metal Dermatoses II. dermatologist 47: 400-409
- Nonaka H et al (2003) Gold allergy in Japan. Contact Dermatitis 48: 112-114