Glut-1

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 21.08.2021

Dieser Artikel auf Deutsch

Synonym(s)

erythrocyte/brain hexose facilitator; Glucose transporter protein

Requires free registration (medical professionals only)

Please login to access all articles, images, and functions.

Our content is available exclusively to medical professionals. If you have already registered, please login. If you haven't, you can register for free (medical professionals only).


Requires free registration (medical professionals only)

Please complete your registration to access all articles and images.

To gain access, you must complete your registration. You either haven't confirmed your e-mail address or we still need proof that you are a member of the medical profession.

Finish your registration now

DefinitionThis section has been translated automatically.

GLUT-1 is a protein of the cell membranes of erythrocytes and cells of the blood-brain barrier. Functionally, it is a transport protein (glucose transporter), a glycoprotein with a molecular mass of 55,000, which enables the introduction of glucose (and other sugars) and vitamin C into the cell interior via a channel. GLUT-1 regulates the glucose uptake in erythrocytes and the brain substance. The coding gene on chromosome 1 is called SLC2A1 gene (solute carrier family 2, facilitated glucose transporter member 1). Mutations in the SLC2A1 gene can cause the GLUT1 deficit syndrome.

General informationThis section has been translated automatically.

Patients with type 2 diabetes mellitus show decreased expression of GLUT1 and decreased glucose uptake in skeletal muscle cells. In the mesangium cell of the renal glomerula there is an increased expression of GLUT1. This leads to increased glucose uptake and excessive production of extracellular matrix in the kidney. Increased pressure in the capillaries of the renal glomerula or an increase in angiotensin II also promotes the expression of GLUT1. This mechanism is thought to be a cause of renal damage caused by hypertension or obesity(nephrosclerosis). GLUT-1 is a specific marker for all developmental stages of infantile hematoma, is further expressed in other benign vascular tumors (e.g. hemangioma, tufted) but also in malignancies such as malignant melanoma, squamous cell carcinoma of the oral mucosa and various adenocarcinomas. Adenocarcinomas.

A congenital defect of the SLC2A1 gene can lead to GLUT1 deficiency (GLUT1 deficit syndrome).

LiteratureThis section has been translated automatically.

  1. Eichhoff OM et al (2010) The immunohistochemistry of invasive and proliferative phenotype switching in melanoma: a case report. Melanoma Res 20:349-355
  2. High PH (2012) Hemangiomas. dermatologist 63: 112-120
  3. Lokmic Z et al. 2012) Hypoxia and hypoxia signaling in tissue repair and fibrosis. Int Rev Cell Mol Biol 296:139-185
  4. Jeong CW et al (2012) The Role of Hypoxia-Inducible Factor-1α and -2α in Androgen Insensitive Prostate Cancer Cells. Urol Oncol Epub ahead of print
  5. Kobayashi M et al (2012) The relationship between GLUT-1 and vascular endothelial growth factor expression and 18F-FDG uptake in esophageal squamous cell cancer patients. Clin Nucl Med 37:447-452
  6. Mihic-Probst D et al (2012) Tumor cell plasticity and angiogenesis in human melanomas. PLoS One 7:e33571 .

Authors

Last updated on: 21.08.2021

Author: Prof. Dr. med. Peter Altmeyer