Synonym(s)
Fosfomycin trometamol
DefinitionThis section has been translated automatically.
Broad spectrum antibiotic with epoxy structure.
Half-lifeThis section has been translated automatically.
1,5–2,5 h
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Pharmacodynamics (Effect)This section has been translated automatically.
Irreversible inhibition of N-acetylglucosamine-3-0 enolpyruvyl transferase.
Spectrum of actionThis section has been translated automatically.
Citrobacter spp., E. coli, H. influenzae, Klebsiella spp., Morganella morganii, Neisseria gonorrhoeae, Proteus mirabilis and vulgaris, Pseudomonas aeruginosa, Salmonella spp., Serratia spp., Shigella spp., Staphylococcus spp.
IndicationThis section has been translated automatically.
Bone and soft tissue infections, urinary tract infections, burns, meningitis, cholecystitis, respiratory tract infections.
Pregnancy/nursing periodThis section has been translated automatically.
Contraindicated in pregnancy and lactation.
Dosage and method of useThis section has been translated automatically.
- 2-3 times/day 3-5 g i.v. or p.o.
- Children: 100-300 mg/kg bw divided over 3 ED.
- newborns: 100 mg/kg bw/day.
Undesirable effectsThis section has been translated automatically.
Rare gastrointestinal disorders, exanthema, venous irritation, passagere transaminase elevation, headache, severe anaphylactic reactions.
ContraindicationThis section has been translated automatically.
Children < 12 LJ, restriction of kidney function (creatinine clearance < 80 ml/min).
PreparationsThis section has been translated automatically.
Infectofos, Monuril
Prof. Dr. med. Peter Altmeyer