DefinitionThis section has been translated automatically.
Formation of characteristic granulomas after the penetration of foreign bodies into the skin or after the formation of crystalline substances in the organism which act like foreign bodies.
EtiopathogenesisThis section has been translated automatically.
- Traumatic: hair storage(hairdresser's granuloma, milker's granuloma, pilonidal sinus); paraffin, collagens or other filler substances (after cosmetic injection); thread material (leaving non-resorbable wound threads); silicates (falling on sand); spines (cacti, sea urchins, etc.).Talcum (wound powder), beryllium (fluorescent tube fragments); antiperspirants (see below zirconium granuloma), after vaccinations(vaccination granuloma)
- Reaction to endogenous substances: urate crystals(gout tophi), necrotic fatty tissue(lipophilic granuloma).
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Clinical featuresThis section has been translated automatically.
Reddish-brownish or skin-coloured, pinhead to pea-sized, possibly also larger, usually coarse nodules and knots.
HistologyThis section has been translated automatically.
Numerous, possibly very large, disordered giant cells that contain or are attached to foreign body particles (detectable by polarisation optics) (so-called foreign body giant cells). In addition, purely granulomatous infiltrate in the case of fresh granulomas, and fibrosing inflammation with regression of the granulomatous component in the case of a longer period of existence.
TherapyThis section has been translated automatically.
Surgical removal of the foreign body or total excision of the entire lesion. The accompanying inflammatory reaction can be treated with intralesional injections of glucocorticoids such as triamcinolone (e.g. Volon A 10 crystal suspension diluted 1:4 with local anaesthetics such as mepivacaine). In case of silicone granulomas, therapy with retinoids such as isotretinoin (e.g. isotretinoin-ratiopharm; acne normin) 0.5 mg/kg bw/day p.o. for 6 months.
LiteratureThis section has been translated automatically.
- El-Khalawany M et al (2015) Dermal filler complications: a clinicopathologic study with a spectrum of histologic reaction patterns. Ann Diagn Pathol 19:10-15
- Molina-Ruiz AM et al (2015) Foreign Body Granulomas. Dermatol Clin 33:497-523
- Tukenmez Demirci G et al (2015) Is it a sarcoidal foreign body granuloma or a cutaneous sarcoidosis on a permenant eyebrow make-up? J Cosmet Laser Ther 14:1-9
- Zarei M et al(2015) Romanelli P. Dermabrasion: a novel treatment for diffuse silicone granuloma. J Clin Aesthet Dermatol 8:47-49
- Wilk M et al(2015) Lichen planopilaris with foreign-body granuloma. Am J Dermatopathol 37: 90-92
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Incoming links (15)
Beryllium granuloma; Calcinosis, tumour-like; Cheilitis granulomatosa; Dermatofibroma hemosiderin storing; Ear fistula and cyst, congenital; Granuloma; Granulomatoses of the skin; Hairdressing granuloma; Lupoides infiltrate; Milker granuloma; ... Show allOutgoing links (10)
Deodorant granulomas; Glucocorticosteroids; Gouty tophi; Granuloma; Granuloma lipophages; Hairdressing granuloma; Isotretinoin; Milker granuloma; Retinoids; Vaccine granuloma;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer
