Fibromodulin

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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Synonym(s)

FMOD; Small interstitial leucine-rich repeat proteoglycans

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DefinitionThis section has been translated automatically.

Fibromodulin is a 42 kDa collagen-binding keratan sulfate SLRP (small interstitial leucine-rich repeat proteoglycans) expressed in connective tissue and cartilage. It shares a significant sequence homology with other proteoglycans such as biglycan and decorin (Iozzo RV et al (2015). Fibromodulin binds to collagen, regulates (inhibits) collagen fibrillogenesis of collagen types I and III and collagen cross-linking. Furthermore, fibromodulin regulates TGF-beta activities by binding TGF-beta into the extracellular matrix.

General informationThis section has been translated automatically.

FMOD expression is increased in inflammatory, fibrotic and wound healing processes in liver, kidney, lung and skin. It decreases with age so that non-glycated forms of fibromodulin can accumulate in tissues such as cartilage (Kalamajski S et al. 2010).

In scars FMOD regulates fibrotic reactions by interacting with the transforming growth factor (TGF) beta.

LiteratureThis section has been translated automatically.

  1. Iozzo RV et al (2015) Proteoglycan form and function: a comprehensive nomenclature of proteoglycans. Matrix Biol 42:11-55.
  2. Karamanos NK (2017) Matrix pathobiology-central roles for proteoglycans and heparanase in health and disease. The FEBS journal 284:7-9.
  3. Kalamajski S et al (2010) The role of small leucine-rich proteoglycans in collagen fibrillogenesis. Matrix Biol 29:248-253.
  4. Lunde IG et al (2016) Syndecans in heart fibrosis. Cell Tissue Res 365(:539-552.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer