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Fibroma perifollicularD23.9

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Perifollicular fibromas

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HistoryThis section has been translated automatically.

Zackheim and Pinkus, 1960

DefinitionThis section has been translated automatically.

Rare follicular fibromas, usually occurring after perifollicular inflammation, e.g. acne. Perifollicular fibromatosis cutis with colonic polyps.

EtiopathogenesisThis section has been translated automatically.

Interpretation on the one hand as a congenital malformation of the connective tissue hair root sheath (perifollicular fibromas can be a partial symptom of Birt-Hogg-Dubé-Syndrome - mutation in the folliculin gene -, on the other hand as fibromatous proliferation of the connective tissue in chronic inflammation. Neurogenic genesis is also discussed (perifollicular neurofibromas)

LocalizationThis section has been translated automatically.

Preferably face (centrofacial), chest, upper back.

Clinical featuresThis section has been translated automatically.

Mostly multiple, whitish yellow or skin-coloured, completely symptom-free, approx. 0.5 cm large, follicularly bound, firm papules. Occasionally cobblestone-like aspect.

HistologyThis section has been translated automatically.

Cystically dilated hair follicle portions filled with horn material, surrounded by concentric lamellae of collagenous connective tissue. Lack of elastic fibres.

TherapyThis section has been translated automatically.

A therapy of benign skin tumors is usually not necessary. Possibly surgical removal of individual lesions by means of curettage or dermabrasion. In view of the syndromal occurrence of perifollicular fibroma and intestinal polyps(Hornstein-Knickenberg syndrome), an endoscopic examination is recommended.

LiteratureThis section has been translated automatically.

  1. Cho S, Hahm JH (1999) Perifollicular fibroma. J Eur Acad Dermatol Venereol 13: 46-49
  2. Drummond C et al (2002) Birt-Hogg-Dube syndrome and multinodular goitre. Australas J Dermatol 43: 301-304
  3. Gotz G, Paul E (2001) Multiple fibrofolliculomas. dermatologist 52: 824-827
  4. Nam JH et al (2011) A case of perifollicular fibroma. AnnDermatol 23:236-238
  5. Schachtschabel AA et al. (1996) Perifollicular fibroma of the skin and colonic polyps: Hornstein-Knickenberg syndrome. dermatologist 47:304-306
  6. Shvartsbeyn M et al (2012) Perifollicular fibroma inBirt-Hogg-Dubé syndrome: an association revisited. J Cutan Pathol 39:675-679
  7. Vakilzadeh F et al (1976) Perifollicular fibroids. Z Hautkr 51: 1039-1041
  8. Zackheim HS, Pinkus H (1960) Perifollicular fibromas. Arch Dermatol 82: 913-917

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer