Fibroma calcifying aponeurotic

Keasbey 1953

Rare, benign, mostly painless (localization-related also painful), mostly subcutaneously localized, fibroblastically differentiated plate-like or nodular neoplasm, which occurs in adolescents on the palms of the hands and/or soles of the feet. Less frequent localisations are trunk or other parts of the extremities.

Unencapsulated, infiltrating, fibroblastically differentiated, dense tumor proliferates alternate with epithelioid cells with plump to oval nuclei in hyaline stroma. No signs of increased cell proliferation, no cell atypes. Striking map-like calcification areas with giant cells. The tumor cells express focal alpha-smooth muscle actin, S-100 protein, EMA protein, CD99.

Molecularly, a specific FNI-EGF fusion with expression of the epidermal growth factor (EGF) was described (Puls F et al. 2016).

Excision is the therapy of choice

1. Choi SJ et al (2008) Calcifying aponeurotic fibroma with osseous involvement of the finger: a case report with radiologic and US findings. Korean J Radiol 9:91-93.

2. Corominas L et al (2017) Calcifying aponeurotic fibroma in children: our experience and a literature review. J Pediatrics Orthopedic B 26:560-564.

3. Giuffre JL et al (2011) Recurrent calcifying aponeurotic fibroma of the thumb: case report. J Hand Surg On 36:110-115.

4. Puls F et al (2016) FN1-EGF gene fusions are recurrent in calcifying aponeurotic fibroma. J Catholic 238:502-507.

5. Rahmi M et al (2002) Juvenile aponeurotic fibroma. A case report with a review of the literature. Chir Main 21:33-35.
6. Schonauer F et al (2012) Calcifying aponeurotic fibroma of the distal phalanx. J Plast Reconstr Aesthet Surg 66:e47-49.