Fibroelastic connective tissue nevusD48.-
Synonym(s)
HistoryThis section has been translated automatically.
Feraudy and Fletcher 2012
DefinitionThis section has been translated automatically.
Rare, slow-growing, nodular or plate-like connective tissue hamartoma that can become clinically evident as early as infancy.
Occurrence/EpidemiologyThis section has been translated automatically.
w:m=6:4 (not representative for n=25)
ManifestationThis section has been translated automatically.
A larger series (n=25) showed an age distribution between 1.5 months and 58 years. In the meantime 3 cases with congenital manifestation have been described (Bouaoud J et al. 2018).
LocalizationThis section has been translated automatically.
Trunk, head, neck, extremities (Pennacchia I et al. 2017).
Clinical featuresThis section has been translated automatically.
Symptomless, moderately firm, skin-coloured or brownish, plate-like or nodular neoplasm, which can be displaced over the base and whose size ranges from 0.3-2.0 cm.
HistologyThis section has been translated automatically.
Below a papillomatous epidermis in the reticular dermis there are fuzzy, fascicularly arranged proliferates of myofibroblasts (the cells stain positively for CD34 and focally for smooth muscle actin; no increase of proliferation factors). The proliferates spread to the subcutaneous fatty tissue (de Feraudy S, Fletcher CD 2012). There are no indications of malignancy.
Differential diagnosisThis section has been translated automatically.
Hypertrophic scar, dermatofibroma, dermatomyofibroma, piloleiomyoma, plaque-like CD34-positive dermal fibroma, lipofibromatosis, superficial desmoid fibromatosis.
Progression/forecastThis section has been translated automatically.
The cases observed so far showed neither recurrence nor metastasis (Pennacchia I et al. 2017).
LiteratureThis section has been translated automatically.
- Bouaoud J et al (2018) Congenital fibroblastic connective tissue nevi: Unusual and misleading presentations in three infantile cases. Pediatric Dermatol 35:644-650.
- de Feraudy S, Fletcher CD (2012) Fibroblastic connective tissue nevus: a rare cutaneous lesion analyzed in a series of 25 cases. On J Surg Pathol 36:1509-155.
- Pennacchia I et al (2017) Fibroblastic connective tissue nevus: Clinicopathological and immunohistochemical study of 14 cases. J Cutan Pathol 44:827-834.