Febris undulantA23.8

Author:Prof. Dr. med. Peter Altmeyer

Last updated on: 29.10.2020

Synonym(s)

Bang's disease; Febris undulans bovina; M. Bang; undulant fever

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HistoryThis section has been translated automatically.

Marston, 1861; Bruce, 1887; Bang, 1897

DefinitionThis section has been translated automatically.

Notifiable anthropozoonosis caused by infection with brucells (Gram-negative aerobic rods). S.u. Brucellosis.

PathogenThis section has been translated automatically.

Mostly Brucella abortus.

Clinical featuresThis section has been translated automatically.

After the stage of bacteremia with undulating fever, granulomatous inflammation occurs, especially in the lymph nodes, spleen and liver.
Skin changes are rare (< 5% of cases): macular exanthema, also multiform; erythema nodosum is also possible. Lupus erythematosus-like facial lesions have also been described.

External therapyThis section has been translated automatically.

Symptomatically e.g. with lotio alba.

Internal therapyThis section has been translated automatically.

Agent of choice is Doxycycline 2.5 mg/kg bw/day p.o. for 6 weeks. For severe infections, combination with rifampicin (e.g. 600-900 mg/day p.o.).
Reservative: Streptomycin can be given additionally in severe cases, (e.g. Streptomycin-Heyl) 1.2 g i.m. over 2 weeks.
Alternatively, cotrimoxazole (e.g. Eusaprim), gentamicin (e.g. Refobacin), gyrase inhibitors such as Ofloxacin (e.g. Tavanic) are used.

Progression/forecastThis section has been translated automatically.

In about 5-10% of the treated cases relapses occur. With therapy in the acute phase (during the first 3 months after infection) the chances of recovery are almost 100%, later 60-80%.

LiteratureThis section has been translated automatically.

Bang B (1897) The etiology of infectious discarding. Z Veterinary Medicine 1: 241-278
Bruce D (1887) Note on the discovery of a microorganism in Malta fever. Practitioner (London) 39: 161-170
Marston JA (1861) Report on fever (Malta). Royal Army Med Dept Rep 3: 486-521
Weber A (2004) Topical epidemiology of selected bacterial zoonoses. Public Health 66(Suppl1): 26-30

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer