Erythema papulatum centrifugum L53.1

Watanabe, 1962

Rare figured, often anular, recurrent exanthema described mainly in the Japanese literature (to date just over 150 cases have been described).

Adulthood; m>w

Viral infections e.g. by parvoviruses? (Nakagawa H et al. 2020).

V.a. Extermities

Erythema papulatum centrifugum (EPC) differs from other well-described figural exanthemas. It is characterized by a:

• Recurrent, expanding exanthema with anular or circular red plaques surrounded by punctate (eccrine associated) red papules.

The lesions occur periodically in episodes and (apparently) resolve completely in the interim.

Patients have no other associated cutaneous or internal diseases.

The histopathologic feature shows superficial perivascular inflammation paracecrine infiltrates.

Erythema anulare centrifugum

1. Franco A et al (2018) A pruritic annular eruption: answer. Am J Dermatopathol 40: 386.
2. Nakagawa H et al. (2020) Parvovirus Infection Diagnosed Using the Patient's smartphone photographs. Intern Med 59: 3257-3258.
3. Ohmori R et al. (2013) A new type of annular erythema with perieccrine inflammation: erythema papulatum centrifugum. Dermatology 226: 298- 301.
4. Rodríguez-Lomba E et al.(2018) An atypical figurate erythema with seasonal recurrences. JAMA Dermatol154: 1340- 1341.
5. Song Z et al. (2012) Erythema papulosa semicircularis recidivans: a new reactive dermatitis? Dermatitis 23: 44- 47.
6. Valencia-Herrera A et al. (2023) Asymmetrical Periflexural Exanthema Associated with SARS-CoV-2 Infection in a Paediatric Patient. Acta Derm Venereol 103:adv00839.
7. Zhang LW et al. (2020) Erythema papulatum centrifugum and new diagnostic criteria. Australas J Dermatol 61:e87-e90.