Erythema palmare et plantar symptomaticum L53.8

Acquired (polyetiologic), completely asymptomatic permanent erythema on the palms of the hands, especially the pads of the thumbs, little fingers, flexor surfaces of the terminal phalanges.

Common in:

• chronic liver diseases (red liver palms in combination with leukonychia and nevi aranei - see also liver diseases and skin changes)
• chronic polyarthritis (rheumatoid arthritis)
• carcinomas
• systemic lupus erythematosus
• diabetes mellitus
• hyperthyroidism
• M. Crohn's disease (see below Enteritis regionalis skin changes)
• vegetative dystonia (nicotine abuse)
• Gravidity.

A very rare and little noticed disease is Erythema palmare et plantare hereditarium (also called"Lane's red palms"), an autosomal dominant inherited palmoplantar erythema without further symptoms.

No causal therapy known. Treatment of the respective underlying disease.

1. Kluger N et al (2010) Erythema palmare hereditarium (Lane's red palms): a forgotten entity? J Am Acad Dermatol 63:e46
2. Langenauer J (2014) Erythema Palmare Hereditarium ('Red Palms', 'Lane's Disease'). Case Rep Dermatol 6:245-247