Synonym(s)
epidermolytic hyperkeratosis (e); Hyperkeratosis epidermolytic
DefinitionThis section has been translated automatically.
Dermatohistopathological reaction pattern of the epidermis characterized by hyperkeratosis with orthokeratosis, hypergranulosis and cytolysis in the upper layers of the stratum spinosum and stratum granulosum. The basal epithelial cells show a granular eosinophilic degeneration with bright cytoplasm and clumped keratohyalin granules. Electron microscopy reveals suprabasal keratinocytes with irregularly aggregated intermediate keratin filaments.
Prof. Dr. med. Peter Altmeyer