Eosinophilic ulcer of the oral mucosa K12.1

The eosinophilic ulcer of the oral mucosa is a rare, benign, painful, self-limited lesion (rarely a recurrent course) of unknown etiology, usually lasting several weeks (months).

Unknown, traumatic (Sah K et al. 2017)?

Any age; advanced adulthood is preferred; no sex predilection.

Oral mucosa, preferably on the tongue

Initially circumscribed nodular infiltrate, early ulceration. A solid, greasy, painful, 0.5-2.0 cm ulcer with prominent, firm margins persists (Lingaraju N et al. 2015).

Ulcer extending to the submucosa and the musculature with mixed-cell inflammatory infiltrate with prominent eosinophilia. No cell atypia observed. The determination of CD30+ cells is important for the differential diagnostic differentiation from the lymphomatoid papulose of the oral mucosa.

Squamous cell carcinoma, lymphoma of the oral mucosa; an etiopathogenetic relationship to the (rare) form of the oral lymphomatoid papulose is unclear (Schwartz Z et al. 2017).

Characteristic is the limited course of 1-5 months, whereby the ulcer can heal spontaneously after probiotic biopsy.

Sugaya N et al. described a recurrent course over a period of 2.5 years.

Typical is the therapy resistance to the usual topical agents.

1. Didona D et al (2015) Eosinophilic ulcer of the tongue--Case report. An Bras Dermatol 90(3 Suppl 1):88-90.
2. Lingaraju N et al. (2015) Eosinophilic ulcer of the tongue: a rare and confusing clinical entity. BMJ Case Rep pii: bcr2015210107
3. Sah K et al (2017) Eosinophilic ulcer of the tongue masquerading as malignant ulcer: An unexplored distinct pathology. J Oral Maxillofac Pathol 21:321.
4. Schwartz Z et al (2017) Oral lymphomatoid papulosis type C: A diagnostic pitfall, often confused with T-cell lymphoma. Ann Diagn Pathol 31:50-55.
5. Sugaya N et al (2018) Recurrent Oral Eosinophilic Ulcers of the Oral Mucosa. A Case Report. Open Dent J 12:19-23.