Ema

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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Synonym(s)

epithelial; Epithelial membrane antigen; membrane antigen; Membrane Antigen

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DefinitionThis section has been translated automatically.

Acronym for "epithelial membrane antigen."

General informationThis section has been translated automatically.

An antigen that forms part of a group of glycosylated proteins molecular weight (259 - 400 kD), which is detectable on a large number of epithelia and occurs in milk fat. The antigen is also known as human milk fat globulin.

Note(s)This section has been translated automatically.

Antibodies against the epithelial membrane antigen are used in histopathology to differentiate less differentiated epithelial tumors (see literature). Squamous cell carcinomas of the surface epithelium stain with EMA (the normal epidermis shows no reactivity). EMA is often used in parallel with cytokeratin antibodies or CEA antibodies. The antibody can cross-react in CD30-positive anaplastic large cell lymphomas.

LiteratureThis section has been translated automatically.

Sajin M et al (2014) Trichilemmal carcinoma - a rare cutaneous malignancy: report of two cases. Rome J Morphol Embryol 55:687-691

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer