Synonym(s)
Elastofibroma cutis; elastofibroma dorsi; Elastofibroma of the back
HistoryThis section has been translated automatically.
Jarvi and Saxen, 1961
DefinitionThis section has been translated automatically.
Rare, benign, subcutaneously palpable, clinically symptom-free, solid tumour (node), predominantly located in the scapular region.
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Occurrence/EpidemiologyThis section has been translated automatically.
About 300 cases have been described worldwide. About 2/3 of all published cases come from a family line in southern Japan (Okinawa).
EtiopathogenesisThis section has been translated automatically.
Degenerative processes and repeated microtraumas under mechanical stress are discussed. Genetic disposition (familial occurrence possible). Possible genetic defect on chromosome Xq12-q22.
ManifestationThis section has been translated automatically.
Occurs at an advanced age, usually after the 35th year of life (average 7th decade). Women are affected much more often than men.
LocalizationThis section has been translated automatically.
Mainly scapula area located below the fascia (> 80% of cases), also lumbar region, upper arm, hip and foot.
Clinical featuresThis section has been translated automatically.
Predominantly isolated, asymptomatic, rarely slightly painful, 4-12 cm large, skin-coloured, not very conspicuous lump, which is fused with the covering skin. In about 10% of patients there is bilateral, mostly asynchronous growth. Adhesions with deeper structures (muscles) are possible. In these cases the nodules are considered pathological.
HistologyThis section has been translated automatically.
Tumorous structural change of the collagenous connective tissue localized in the dermis and spreading to the subcutaneous fatty tissue. There are broad, cell-poor, lumpy collagenous ligaments with a staining behaviour like elastotic material. These are partly wavy, partly fragmented and fluoresce greenish. Isolated islands of fatty tissue.
Immunohistochemistry: Numerous myofibroblasts of the VAD-type, some CD34- and S100-positive cells.
Differential diagnosisThis section has been translated automatically.
TherapyThis section has been translated automatically.
If symptomatic, excision without greater safety margin (no evidence of malignant degeneration).
Progression/forecastThis section has been translated automatically.
Excision is curative. Recurrences have so far only been proven by casuistry (probably after incomplete excision!).
LiteratureThis section has been translated automatically.
- Alberghini M et al (2003) Elastofibroma associated with high grade leiomyosarcoma of the soft tissues: a light and ultrastructural study of one case. J Submicrosc Cytol Pathol 35: 43-48
- Alberghini M et al (2004) Histochemical and ultrastructural study of an elastofibroma dorsi coexisting with a high grade spindle cell sarcoma. Eur J Histochem 48: 173-178
- Dalal A (2003) Sonographic detection of elastofibroma dorsi. J Clin Ultrasound 31: 375-378
- Guha AR et al (2004) Elastofibroma dorsi--a case report and review of literature. Int J Clin Pract 58: 218-220
- Jarvi OH, Saxen AE (1961) Elastofibroma dorsi. Acta Pathol Microbiol Scand 144: 83-84
- Kara M (2002) Bilateral elastofibroma dorsi: proper positioning for an accurate diagnosis. Eur J Cardiothorac Surgery 22: 839-841
- Muller LP et al (1999) Bilateral elastofibroma dorsi. Surgeon 70: 1357-1360
- Nishio JN et al (2002) Gain of Xq detected by comparative genomic hybridization in elastofibroma. Int J Mol Med 10: 277-280
- Nishida A et al (2003) Bilateral elastofibroma of the thighs with concomitant subscapular lesions. Skeletal radiol 32: 116-118
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Incoming links (1)
Elastofibroma dorsi;Outgoing links (5)
Excision; Keloid (overview); Lipoma (overview); Liposarcoma; Pseudoxanthoma elasticum;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer