Synonym(s)
immediately early gene response-1
DefinitionThis section has been translated automatically.
Acronym for "immediately early gene response-1". EGR1 is an inducible transcription factor belonging to the DNA-binding zinc finger proteins. This transcription factor represents a biologically early activation gene. Egr1 regulates the expression of many genes involved in inflammatory processes. Transcription factors may play a crucial role in the pathogenesis of psoriasis vulgaris as well as rheumatoid arthritis.
Note(s)This section has been translated automatically.
Egr1 is expressed in synovial fibroblasts of patients with rheumatoid arthritis and in lesioned skin of psoriasis patients. Increased expression of TIMP1 (tissue inhibitor of metalloproteinases), TIMP3 and collagen type II at the transcript level was observed in several cell lines overexpressing Egr-1.
LiteratureThis section has been translated automatically.
- Fang M et al (2007) Evidence of EGR1 as a differentially expressed gene among proliferative skin diseases. Genomic Med 1: 75-85
Prof. Dr. med. Peter Altmeyer