Ecallantide

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 01.08.2022

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Definition
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A genetically engineered biopharmaceutical consisting of 60 amino acids for the treatment of hereditary angioedema, which belongs to the group of so-called "Kunitz domain peptides" and is effective as an inhibitor of the enzyme kallikrein. In a clinical study (EDEMA3) on 36 patients with hereditary angioedema, Ecallantid performed better than placebo.

Pharmacodynamics (Effect)
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As a selective inhibitor of the enzyme kallikrein, Ecallantid inhibits the production of the bradykinin responsible for swelling. Ecallantide intervenes in the kallikrein-kinin pathway at a later stage than the C1 esterase inhibitor.

Field of application/use
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Hereditary angioedema; ecallantide is a selective inhibitor of the enzyme kallikrein, the drug thus inhibits the production of the bradykinin responsible for the swelling. Ecallantide intervenes in the kallikrein-kinin pathway at a later stage than the C1 esterase inhibitor.

Undesirable effects
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4% of patients react with anaphylactic reactions to the active substance; nausea, fatigue, headaches, diarrhoea are also observed at ADRs. Respiratory infections, fever, vomiting, itching and upper abdominal pain occurred in > 5% of patients.

Preparations
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Calbitor (on the US market, but not on the European market)

Literature
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  1. Krome S (2010) therapy is making progress. Nude Dermatol 37:5
  2. Schneider L et al (2007) Critical role of kallikrein in hereditary angioedema pathogenesis: a clinical trial of ecallantide, a novel kallikrein inhibitor. J. Allergy Clin. Immunol 120:416-422

Incoming links (1)

Angioedema hereditary 1;

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Last updated on: 01.08.2022