Dysmaturation epidermal

Histological phenomenon that can occur in skin reactions induced by chemotherapeutic or biological agents (e.g. in the hand-foot syndrome). Pathogenetically it is a drug-induced maturation disorder of the epidermis. The histological picture is characterized by dyskeratoses, nuclear atypias and suprabasal mitoses (also atypical mitosis figures = star-burst-cells).

1. Kerl H et al (2016) Cutaneous drug reaction. In: Ceroni L et al (Hrsg) Histopathology of the skin. P. 196-197 Springer-Verlag GmbH Berlin-Heidelberg
2. Llamas-Velasco M et al (2016) Regorafenib induced hand-foot skin reaction with striking epidermal dysmaturation- a new histopathological pattern associated with the use of multi-kinase inhibitors. Br J Dermatol doi: 10.1111/bjd.14417