Synonym(s)
Bullous drug exanthema; Vesicular drug exanthema; vesiculo-bullous drug exanthema
DefinitionThis section has been translated automatically.
Maximum variant of drug-induced, possibly severe, cutaneous hypersensitivity reactions.
ClassificationThis section has been translated automatically.
Classification of drug-induced bullous exanthema:
- Drug exanthema, fixed, toxic
- Toxic epidermal necrolysis (Lyell syndrome, drug-induced)
- Erythema exudativum multiforme (EEM)
- Stevens-Johnson syndrome (SJS)
- Pustulose, acute generalized exanthematic (AGEP)
- Exanthema, phototoxic
- Coma bubbles (barbiturate bubbles)
- Drug-induced bullous autoimmune diseases:
EtiopathogenesisThis section has been translated automatically.
Blistering in drug exanthema is a clinical sign of a severe drug reaction. Primarily CD8-positive cells are involved in the bullous reaction (in contrast to the maculo-papular drug exanthema). These are highly cytotoxic, lead to severe epidermal destruction (by formation of perforin and granzyme B), as they recognize drugs (or metabolites) in connection with the MHC-CLasse I molecules found on all keratinocytes.
LiteratureThis section has been translated automatically.
- Yawalkar N, Pichler WJ (2005) Mechanisms of cutaneous drug-induced reactions. JDDG 2: 1013-1021
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Outgoing links (11)
Acute generalized exanthematous pustulosis; Coma bubbles; Epidermolysis bullosa acquisita; Erythema multiforme; Fixed drug eruption; Linear IgA dermatosis; Pemphigoid bullous; Pemphigus vulgaris; Perforin; Stevens-johnson syndrome; ... Show allDisclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer