Synonym(s)
DEC
DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
9–13 h
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Pharmacodynamics (Effect)This section has been translated automatically.
Immobilization and inhibition of muscle activity.
Spectrum of actionThis section has been translated automatically.
Filaria (Brugia malayi, Loa loa, Onchocerca volvulus and Wucheria bancrofti), Larva migrans by Toxocara spp.
IndicationThis section has been translated automatically.
Dosage and method of useThis section has been translated automatically.
- Brugia malayii: 3 times 2 mg/kg bw/day p.o. for 3-4 weeks.
- Brugia timori: 3 times 5 mg/kg bw/day for 2-3 weeks.
- Loa loa: 3 times 2 mg/kg bw/day for 3-4 weeks or 50 mg on day 1; 2 times 50 mg on day 2; 3 times 50 mg on day 3; 2 times 100 mg on day 4; 3 times 100 mg on day 5.
- Mansonella ozzardi: 3 times 6 mg/kg bw/day for 10 days.
- Onchocerca volvulus: 50 mg on day 1; 100 mg on day 2; 200 mg on day 3; 2 times 200 mg on day 4; 3 times 200 mg on day 5-12.
- Toxocara spp.: 3 times 2 mg/kg bw/day for 4 weeks.
- Wucheria bancrofti: 3 times 2 mg/kg bw/day for 3-4 weeks.
Notice! The often quite violent reactions in case of onchocerciasis (mazzotti reaction with danger of blindness) can be intercepted by administration of dexamethasone. Before therapy of onchocerciasis, a stronger eye infestation should be excluded!
Undesirable effectsThis section has been translated automatically.
Allergic reactions, nausea, fever, headaches, tremor, vision and balance problems, ataxia.
Notice. The death of the parasites or larvae stages results in the release of allergens, which can cause severe allergic reactions!
ContraindicationThis section has been translated automatically.
Epilepsy, renal insufficiency.
PreparationsThis section has been translated automatically.
Hetrazan; Banocide (both preparations are not approved in Germany and are available from international pharmacies)
Prof. Dr. med. Peter Altmeyer