Login required. Please login into your account or register.
DefinitionThis section has been translated automatically.
Antimicrobial peptide. Is released in the eccrine sweat glands of the skin.
General informationThis section has been translated automatically.
- As a precursor protein, dermicidin is first proteolytically cleaved to form active, antimicrobial derivatives (e.g. DCD-1). The concentration in sweat is about 1-10 μg/ml. These already have a toxic effect on microorganisms.
- DCD-1 showed in vitro sensitivity to Staph. aureus, E. coli, E. faecalis and Candida albicans.
- It is constitutively secreted via eccrine sweat glands and spreads with the sweat over the entire skin.
- Remains stable in the acid mantle of the skin.
- Excessive and too frequent washing probably has a negative effect on the distribution of dermicidin.
- Patients with atopic dermatitis have a reduced dermcidin content in their sweat.
LiteratureThis section has been translated automatically.
- Rieg S et al (2006) Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites. J Invest Dermatol 126: 354-365
Prof. Dr. med. Peter Altmeyer