DefinitionThis section has been translated automatically.
Antimicrobial peptide. Is released in the eccrine sweat glands of the skin.
General informationThis section has been translated automatically.
- As a precursor protein, dermicidin is first proteolytically cleaved to form active, antimicrobial derivatives (e.g. DCD-1). The concentration in sweat is about 1-10 μg/ml. These already have a toxic effect on microorganisms.
- DCD-1 showed in vitro sensitivity to Staph. aureus, E. coli, E. faecalis and Candida albicans.
- It is constitutively secreted via eccrine sweat glands and spreads with the sweat over the entire skin.
- Remains stable in the acid mantle of the skin.
- Excessive and too frequent washing probably has a negative effect on the distribution of dermicidin.
- Patients with atopic dermatitis have a reduced dermcidin content in their sweat.
LiteratureThis section has been translated automatically.
- Rieg S et al (2006) Generation of multiple stable dermcidin-derived antimicrobial peptides in sweat of different body sites. J Invest Dermatol 126: 354-365
Prof. Dr. med. Peter Altmeyer