Dermcidine

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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General definition
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Dermcidins (DCD) are antimicrobial peptides (AMP) produced in human sweat glands. A derivative that has been studied in atopic eczema is the antimicrobial peptide (AMP) Dermcidin DCD-1L. Dermcidin DCD-1L, which is produced from a precursor by proteolytic cleavage, is distributed on the skin surface with sweat. Dermcidin remains stable on the skin surface and has amphiphilic properties.

Dermcidin DCD-1L acts antimicrobially like a "broad-spectrum antibiotic". The antimicrobial effect against Escherichia coli and staphylococci is well known. Furthermore it has an antifungal effect e.g. against Candida albicans.

The AMP Dermcidin DCD-1L, together with other AMPs, is primarily reduced in patients with atopic eczema . This explains the increased bacterial and viral infection rate of these patients (s.a. psoriasis vulgaris).

Literature
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  1. Mena-Bravo A et al (2013) Sweat: a sample with limited present applications and promising future in metabolomics. J Pharm Biomed Anal. 2014 90:139-147
  2. Ryu S et al (2014) Colonization and infection of the skin by S. aureus: immune system evasion and the response to cationic antimicrobial peptides. Int J Mol Sci 15:8753-8772
  3. Schittek B et al.(2008)The role of antimicrobial peptides in human skin and in skin infectious diseases. Infect Disord Drug Targets. 2008 8:135-143
  4. Shiohara T et al (2011) Defective sweating responses in atopic dermatitis. Curr Probl Dermatol 41:68-79

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Last updated on: 29.10.2020