DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
5 h
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Pharmacodynamics (Effect)This section has been translated automatically.
IndicationThis section has been translated automatically.
Limited indicationThis section has been translated automatically.
In children and adolescents < 16 years, heart failure, renal failure, prostate hypertrophy. Caution also in epilepsy, migraine, hemophilia patients.
Dosage and method of useThis section has been translated automatically.
200-800 mg/day p.o. in 2-4 doses under regular control ofC1-esterase inhibitor activity.
Remember! Before starting therapy, during therapy and up to one month after discontinuing the preparation, pregnancy must be ruled out in women of childbearing age and effective contraception must be exercised!
Undesirable effectsThis section has been translated automatically.
Major side effects are acne vulgaris, weight gain, libido changes, virilisation, irregular menstrual bleeding, deepening of the voice (in contrast to the other side effects, this is not reversible; patients must be informed about this)!
InteractionsThis section has been translated automatically.
See Table 1.
ContraindicationThis section has been translated automatically.
Pregnancy, lactation, singing (voice deepening), severe liver disease, thromboembolic diseases, androgen-dependent tumors, hyperlipoproteinemia, hypercalcemia, hypercalzuria, breast or prostate cancer in the medical history.
PreparationsThis section has been translated automatically.
Danadrol (available through the international pharmacy)
Note(s)This section has been translated automatically.
Until 2006, the active ingredient was approved in the Federal Republic of Germany for various indications, including as a contraceptive, for the treatment of endometriosis and hereditary angioedema, for the treatment of cycle disorders and lumps in the breast. After 2006 the approval in the FRG/EU expired. However, the active ingredient is available through international pharmacies as an imported drug.
Notice! Due to its status as an imported drug, the health insurance company must clarify any cost transfer before starting treatment for angioedema.
TablesThis section has been translated automatically.
Main interactions of Danazol
Antidiabetics, oral |
Carbohydrate tolerance changed |
Anticoagulants, oral |
Anticoagulant effect ↑ |
Carbamazepine |
Carbamazepine effect ↑ |
Insulin |
Hypoglycaemia |
Contraceptives, oral |
Anabolic effect ↓ |
Prof. Dr. med. Peter Altmeyer