Dacarbazine
Synonym(s)
DTIC
DefinitionThis section has been translated automatically.
Antimetabolite, prodrug.
Half-lifeThis section has been translated automatically.
5 h
IndicationThis section has been translated automatically.
Metastatic malignant melanoma as mono- or combination therapy, sarcomas, M. Hodgkin.
Dosage and method of useThis section has been translated automatically.
- According to chemotherapy protocol:
- monotherapy:
- 200-250 mg/m2 KO/day IV, day 1-5, every 21-28 days.
- 850-1200 mg/m2 KO/day i.v., day 1, every 21-28 days.
- In combination therapies according to the following schemes:
- BHD, BVD, BOLD, DVP, DBCT, DTIC-INFα, DTIC-IL2.
Remember! Women and men must use effective contraception during the therapy and until 6 months after the end of the therapy. In the case of high-dose chemotherapy, men should have a spermiogram before and after therapy and be made aware of the possibility of cryopreserving sperm!
Undesirable effectsThis section has been translated automatically.
- Cutaneous adverse reactions: photosensitivity, pruritus, erythema, allergic reactions.
- Extracutaneous UAWs: BB changes, gastrointestinal disturbances, Budd-Chiari syndrome, renal damage, headache, flu-like symptoms, transaminase elevation.
Reminder. During therapy, regular checks of GOT and GPT as well as blood count!
In the event of a sudden increase in transaminases or eosinophilia > 30%, discontinue dacarbazine and administer glucocorticoids and heparin !
InteractionsThis section has been translated automatically.
Cytostatic drugs lead to a mutual increase in toxicity.
ContraindicationThis section has been translated automatically.
Pregnancy, lactation, leukopenia and/or thrombopenia, severe liver or kidney disease.
PreparationsThis section has been translated automatically.
Detimedac
LiteratureThis section has been translated automatically.
- Hauschild A et al (2008) systemic therapy of melanoma. Current clinical studies. dermatologist 59: 484-492