Cromoglicic acid

Synonym(s)

Acidum cromoglicium; CAS No: 16110-51-3; Cromolyn; Disodium cromoglicic acid

Definition
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Cromoglicic acid is an antiallergic, antihistamine, mast cell stabilizer.

Pharmacodynamics (Effect)
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Inhibits the release of mediators (including histamine, PAF) by stabilizing the membranes of the mast cell by blocking chloride channels Cromoglicic acid has a half-life of 60 - 90 minutes. Therefore, the substance must be applied at least 4 times/day.

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Indication
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The active substance is used mainly in the prevention of bronchial asthma, allergic rhinitis and allergic conjunctivitis.

Dosage and method of use
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Adults: 4 times/day 2 capsules p.o., Children from 2 to 4 years: 4 times/day 1 capsule p.o.
Nasal spray: 4 times/day 1 spray in each nostril.
Dosage aerosol: 4-8 times/day 2 sprays per inhalationem
Eye drops: 4 times/day 1 trp. instill.

Undesirable effects
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Since cromoglicic acid is almost completely broken down when taken, the active ingredient is only used locally or by inhalation. Side effects include local irritation such as coughing, hoarseness, and rarely bronchospasm or myalgia.