Cribriform apocrine carcinoma of the skin

Requena 1998

Carcinoma classified as low-risk carcinoma, which is considered a histopathological variant of apocrine carcinomas.

Young adults (mean age of the disease: 47.8 years) with preference for the female sex

Proximal parts of the upper and lower extremities

1.0-2.0 cm in size, slowly developing over a period of 1-2 years, mostly surface-smooth, painless (a slight sensitivity to pressure may be present) solid plaques or flat protuberant nodules. Clinically the tumours are classified as dermatofibromas or scar keloids.

In the middle and deep dermis, spreading to the subcutis, there are moderately sharply defined, solid, CEA- and pancytokeratin positive, and S 100 and cytokeratin 20 negative tumor aggregates which are characterized by tubular strands embedded in a fibrillar stroma when magnified. The epithelial proliferates are characterized by small and larger holes, which cause the sieve-like (cribriform) aspect. The lumina are optically empty. Individual tubules are lined by cubic or cylindrical cells. Occasional mitoses.

adenoid basal cell carcinoma, metastasis of a breast carcinoma (atypical localization, lack of expression of estrogen or progesterone receptors), metastases of visceral carcinomas, primary cutaneous adenoid-cystic carcinoma (pronounced infiltrative growth with perineural infiltration)

Excision with a small (0.5 cm to all sides) safety distance

After excised tumour on all sides in a healthy person healing. In a larger study of 26 cases none of the patients who were excised in sano developed a recurrence.

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