Complement defectsD84.1

Author:Prof. Dr. med. Peter Altmeyer

Last updated on: 29.10.2020

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DefinitionThis section has been translated automatically.

Congenital defects or dysfunctions of one or more complement components. See tab.

TablesThis section has been translated automatically.

Most common congenital defects of the complement system

Defective complement component	Probable mode of inheritance	Associated clinical symptoms
_C1Q	unknown	Recurrent infections, vasculitis, CGN
_{C1Q dysfunction}	AR (CD)	SLE Syndrome
_C1R	AR	SLE syndrome, CGN
_C1S	unknown	SLE, CGN
_C1S	unknown	SLE
_C4	AR (CD)	SLE, vasculitis CDLE
_C2	AR (CD)	SLE, MPGM, purpura rheumatica, dermatomyositis, pneumococcal sepsis
_C3	AR (CD)	CGN, pyogenic infections with missing granulocytosis
C5	AR (CD)	SLE, pyogenic infections, gonococcal, meningococcal infections
C5 dysfunction	AD	Pyoderma, Sepsis, Erythrodermia desquamativa Leiner
_C6	AR (CD)	Gonococcal and meningococcal infections, SLE syndrome
C7	AR (CD)	Sclerodactyly, CGN, gonococcal and meningococcal infections
C8	AR (CD)	Gonococcal and meningococcal infections, SLE syndrome
C9	AR (CD)	Meningococcal infections
_C1 INH	AD	hereditary angioedema
_C3B INA	AR (CD)	Pyogenic infections

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer