Comedonal Epidermolytic Nevus

Very rare, usually acquired, follicular epidermal hamartoma characterized by follicular, dark to black papules with firm follicular horny pads and acatholytic zones in the epidermis (Zanniello R et al 2019). "Epidermolytic comedone nevus" should be considered a variant of comedone nevus (nevus comedonicus). A linear arrangement of efflorescences is possible (Linear Comedonal Epidermolytic Nevus) (Behera B etg al 2021).

In international literature, the term "epidermolytic nevus" is often equated with "superficial epidermolytic ichthyosis" (OMIM 113800). This leads to confusion and should be avoided.

1. Adya KA et al (2020) Epidermolytic Nevus: An Instance of Mosaic Epidermolytic hyosis. Indian Dermatol Online J 11:272-273 Illustrations!!!
2. Behera B etg al (2021) Linear comedonal epidermolytic nevus: A Rare Entity. Am J Dermatopathol 43:397-399.
3. Mohamad J et al (2021) Epidermolytic epidermal nevus caused by a somatic mutation in KRT2. Pediatr Dermatol 38:538-540.
4. Schecter AK et al (2004) Linear nevus comedonicus with epidermolytic hyperkeratosis. J Cutan Pathol 31: 502-505.
5. Zanniello R et al (2019) Late-Onset Nevus Comedonicus With Follicular Epidermolytic Hyperkeratosis-Case Report and Review of the Literature. Am J Dermatopathol 41:453-455.