Colloidmilium juveniles L72.8

Woolridge and Frerichs 1960

Very rare, probably autosomal recessive inherited disease, which can be pathogenetically distinguished from the adult form of colloidal milium. In this case, there is a focal deposition of colloid as a degradation product of keratinocytes (in contrast to the adult form of colloid milium).

Very rare, < 50 cases known in world literature; m:f=1:1;

Unknown; familial occurrence is described several times. In contrast to the adult form, the juvenile colloidalmilium is a deposited "keratin colloid" in which gap junctions and desmosomes have been detected by electron microscopy.

Manifestation prepubertal; beginning of the first changes in the 6th-7th LJ

Light-exposed areas of the face (cheeks, perioral, periocular)

Gradual development of UV-triggered, symptom-free, soft, translucent, yellowish papules and plaques. On pressure, gelatinous material can be expressed from the lesions after incision.

S.u. Colloidalmilium

S.u. Colloidalmilium

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2. Chowdhury MM et al (2000) Juvenile colloid milium associated with ligneous conjunctivitis: report of a case and review of the literature. Clin Exp Dermatol 25:138-140
3. Hashimoto K et al (1989) Juvenile colloid milium. Immunohistochemical and ultrastructural studies. J Cutan Pathol 16:164-174
4. Martorell-Calatayud A et al (2011) Familial juvenile colloid milium: report of a well documented case. J Am Acad Dermatol 64: 203-206
5. Oskay T et al (2003) Juvenile colloid milium associated with conjunctival and gingival involvement. J Am Acad Dermatol 49:1185-1188
6. Schuster V et al (2006) Juvenile colloid milium and ligneous conjunctivitis are caused by severe hypoplasminogenemia--no evidence for causal relationship to non-Hodgkin's lymphoma. J Eur Acad Dermatol Venereol 20:1368.
7. Woolridge WE et al (1960) Amyloidosis. A new clinical type. Arch Dermatol Syph 82: 230-234