ColloidalmiliumL57.8; L72.8

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 13.07.2024

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Synonym(s)

adult colloidal milium; Colloidal degeneration of the skin; colloidal milium; Degeneration of colloidal skin; elastosis colloidalis conglomerata; Hyalom; pseudomilium colloidale

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HistoryThis section has been translated automatically.

Wagner 1866

DefinitionThis section has been translated automatically.

Circumscribed connective tissue disorder with deposition of a "defective" scleroprotein (colloid) in the papilla tips of light-exposed skin areas.

ClassificationThis section has been translated automatically.

According to the age of manifestation, a distinction is made between the juvenile colloidal milium (see below colloidal milium, juveniles) and the classical colloidal milium of adults.

ManifestationThis section has been translated automatically.

  • Adult or solar form: more common form, especially in chronic light exposure or after contact with photosensitisers. Occurs in adulthood.
  • Juvenile form (rare): occurring before puberty. Autosomal dominant mode of inheritance.

LocalizationThis section has been translated automatically.

Exposed skin areas, especially the middle of the forehead, zygomatic arch, sides of the neck, ears, back of the hand, nose, upper lip, chin.

Clinical featuresThis section has been translated automatically.

Numerous glass pinhead-sized, transparent, exceptionally yellowish-brownish or skin-coloured, soft, grouped papules; after stab incision a jelly-like mass empties under pressure. In adult forms it occurs in combination with other actinic changes such as elastoidosis cutanea nodularis et cystica, cheilitis actinica, cutis rhomboidalis nuchae.

HistologyThis section has been translated automatically.

Homogeneous, circumscribed, amophilic or basophilic, PAS-positive colloidal conglomerates in the upper dermis. The deposits are cell-poor. Typical are the preparation-related cracks and fissures within the colloid nodule. The overlying epithelium is flattened and atrophic. In the adult form, solar elastosis is obligatory, which is missing in the juvenile form. Versch. Investigators could stain the (keratin-)colloid with keratin-AK in the juvenile form (compare keratin-amlyoid in LIchen amyloidosus)

Indirect immunofluorescenceThis section has been translated automatically.

Negative with antibody.

Differential diagnosisThis section has been translated automatically.

Amyloidosis; hyalinosis cutis et mucosae; protoporphyria erythropoetica; adenoma sebaceum; trichoepithelioma; hidrocystoma.

TherapyThis section has been translated automatically.

Diathermy, laser therapy with Erbium-YAG-Laser, curettage or cryosurgery. Experimental dermabrasion.

Note(s)This section has been translated automatically.

Noteworthy is the reference to the concordant occurrence of beta-thalassaemia major and colloid milium (Giordano G et al. 2008).

LiteratureThis section has been translated automatically.

  1. Ammirati CT et al. (2002) Adult-onset facial colloid milium successfully treated with the long-pulsed Er:YAG laser. Dermatol Surg 28: 215-219
  2. Chowdhury MM et al. (2000) Juvenile colloid milium associated with ligneous conjunctivitis: report of a case and review of the literature. Clin Exp Dermatol 25: 138-140

  3. Giordano G et al. (2008) A case of colloid milium in patient with beta thalassaemia major. J Cutan Pathol 35:566-569.

  4. Kirtak N et al. (2002) A case of adult colloid milium with chronic sun exposure. Int J Dermatol 41: 936-938
  5. Lewis AT et al. (2002) Unilateral colloid milium of the arm. J Am Acad Dermatol 46(2 Suppl Case Reports): S5-7
  6. Muscardin LM et al (2000) Papuloverrucous colloid milium: an occupational variant. Br J Dermatol 143: 884-887
  7. Oskay T et al. (2003) Juvenile colloid milium associated with conjunctival and gingival involvement. J Am Acad Dermatol 49: 1185-1188
  8. Schuster V et al (2003) Ligneous conjunctivitis. Surv Ophthalmol 48: 369-388
  9. Schrallhammer-Benkler K et al (1990) Colloid milium. Dermatology 41: 451-454

Authors

Last updated on: 13.07.2024

Author: Prof. Dr. med. Peter Altmeyer