Collodion baby Q80.2

Clinically descriptive term for a perinatal condition that can occur in various forms of ichthyosis. No independent clinical picture. In most cases an autosomal recessive hereditary lamellar ichthyosis (ARCI) is present. However, collodion membranes are also observed in other forms of ichthyosis.

Diffuse redness, lamellar scaling, sometimes brownish, creased, dry, parchment-like skin coating over the entire body. Mostly presence of an ectropion. Combinations with hypotrichosis, nail changes, heart defects, short stature, oligophrenia, microophthalmia, deep corneal clouding or epilepsy are also possible. Skin detachment within a few days to weeks. The further course is different. Often a lamellar ichthyosis (see below Ichthyosis) develops, in some cases the skin completely normalizes within weeks to months. Collodion babies are newborns at risk and require special monitoring.

Different. Depending on the classification of the underlying form of ichthyosis. Approximately 10% of children with collodion skin or congenital ichthyosiform erythroderma experience almost complete healing of the ichthyosis within the first months of life. This is caused by a pressure-sensitive mutation in the transglutaminase 1 gene.

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