Synonym(s)
Clopidogrel
DefinitionThis section has been translated automatically.
Antiplatelets. ADP antagonist.
Pharmacodynamics (Effect)This section has been translated automatically.
Selective inhibition of adenosine diphosphate (ADP)-induced platelet aggregation by binding of the active metabolite of clopidogrel to ADP receptors on the surface membranes of platelets (binding is irreversible and persists throughout the platelet life span of 7-10 days).
Secondarily, ADP-induced binding of fibrinogen to its receptors is blocked, but there is no direct effect on the expression of fibrinogen
In contrast to acetylsalicylic acid, clopidogrel has no inhibitory effect on cyclooxygenase and thus not on the synthesis of thromboxane A2 or prostacyclin.
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IndicationThis section has been translated automatically.
Prevention of arteriothromboses in patients with heart attack, coronary syndromes, cerebral ischemia (apoplexy up to 6 months ago), peripheral arterial occlusive disease, among others.
Pregnancy/nursing periodThis section has been translated automatically.
No use during pregnancy or lactation (insufficient data available).
Dosage and method of useThis section has been translated automatically.
Adults/young people > 18 years: once/day 75 mg p.o.
ContraindicationThis section has been translated automatically.
Hypersensitivity to the active substance, severe liver dysfunction.
PreparationsThis section has been translated automatically.
Plavix, Iscover
Prof. Dr. med. Peter Altmeyer