Cholesterol, extracellular L95.1

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 16.03.2023

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History
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Urbach, 1967

Definition
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Erythema elevatum diutinum with secondary lipid deposits in the connective tissue (see Wolff HH et al. 1978; see also further discussion under Erythema elevatum diutinum).

Manifestation
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Later in life.

Localization
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Extremities, face, neck and buttocks.

Clinical features
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Relapsing, brownish to livid, coarse confluent nodules and infiltrated plaques with a yellowish center. Additionally, facultative efflorescences corresponding to erythema elevatum diutinum with yellowish-brownish hue, in the dependent areas brownish-purple. Reported in association with these skin lesions were hepatosplenomegaly, diffuse or nodular compaction in the area of the lungs.

Histology
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Leucocytoclastic vasculitis, dense mixed cell infiltrate, extracellular cholesterol deposition.

Therapy
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Corresponding to the erythema elevatum diutinum. If necessary experiment with laser treatment(argon,CO2 laser) or electrocautery. See also Xanthelasma.

Progression/forecast
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Chronic, intermittent course, healing of the skin changes with hyperpigmentation or scarring.

Literature
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  1. Urbach E, Epstein E, Lorenz K (1967) Extracellular cholesterolosis. Arch Dermatol Syphil (Berlin) 166: 243-272.
  2. Wolff HH et al (1978) Erythema elevatum diutinum. I. Electron microscopy of a case with extracellular cholesterinosis. Arch Dermatol Res 15:261:7-16.

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Erythema elevatum diutinum;

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Last updated on: 16.03.2023