Chlormethin-Gel

Chloromethine is a cytostatic, a bifunctional alkylate: rapidly proliferating cells are inhibited in growth by binding to DNA, RNA and proteins. This prevents the cells from replicating in the DNA with subsequent cell death.

Chloromethine is approved in Europe for the treatment of patients with mycosis fungoides at all stages of the disease. The optimal treatment regimens in terms of frequency, dosage or maintenance therapy are not yet fully established (Assaf C et al. 2021).

Good results have been achieved in lymphomatoid papulosis (Dege T et al. 2024)

1. Assaf Chalid et al. (2021) Chloromethine gel for the treatment of ycosis fungoides. An expert consensus from Germany, Austria and Switzerland (DACH-REgio) on therapy management. JDDG 20:579-588
2. Dege T et al. (2024) Successful treatment of lymphomatoid papulosis with chlormethine gel. J Dtsch Dermatol Ges 22: 826-827.
3. Geskin LJ et al. (2021) Chlormethine Gel for the Treatment of Skin Lesions in All Stages of Mycosis Fungoides Cutaneous T-Cell Lymphoma: A Narrative Review and International Experience. Dermatol Ther (Heidelberg). 11: 1085-1106
4. Wehkamp U et al. (2021) Management of chlormethine gel treatment in mycosis fungoides patients in two German skin lymphoma centers. J Dtsch Dermatol Ges.19: 1057-1059