DefinitionThis section has been translated automatically.
Selective cyclooxygenase inhibitor (COX-2 inhibitor).
IndicationThis section has been translated automatically.
Symptoms in irritable states of degenerative joint diseases (activated arthroses) or chronic polyarthritis (rheumatoid arthritis).
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Pregnancy/nursing periodThis section has been translated automatically.
Contraindicated in pregnancy and lactation!
Complication(s)This section has been translated automatically.
Cave! Oral anticoagulants (phenprocoumon, warfarin): Bleeding with sometimes fatal outcome! ACE inhibitors: Risk of acute renal failure!
Dosage and method of useThis section has been translated automatically.
- Irritation in degenerative joint diseases (activated arthroses): 200 mg p.o. once/day, if necessary 200 mg p.o. twice/day. Maximum daily dose 400 mg.
- Rheumatoid arthritis: 1-2 times/day 200 mg p.o., maximum daily dose 400 mg.
Notice! Dose adjustment necessary in elderly patients (≥ 65 yrs.) as well as in patients with liver or kidney dysfunction!
ContraindicationThis section has been translated automatically.
Cave!
Sulfamide allergy! Adverse drug reaction after ingestion of acetylsalicylic acid, COX-2 inhibitors or other NSAIDs, active peptic ulcers, gastrointestinal bleeding, inflammatory bowel disease.Notice! Do not use on children!
PreparationsThis section has been translated automatically.
Celebrex Hartkps.
LiteratureThis section has been translated automatically.
- El Hajjaji H et al (2003) Celecoxib has a positive effect on the overall metabolism of hyaluronan and proteoglycans in human osteoarthritic cartilage. J Rheumatol 30: 2444-2451
- Nikolaus T et al (2004) Pharmacological treatments for persistent non-malignant pain in older persons. Drugs Aging 21: 19-41
- Wolfe F et al (2004) Longer use of COX-2-specific inhibitors compared to nonspecific nonsteroidal antiinflammatory drugs: a longitudinal study of 3639 patients in community practice. J Rheumatol 31: 355-358
Prof. Dr. med. Peter Altmeyer
