Cefazolin

Definition
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Older cephalosporin.

Half-life
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1,4–2 h

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Spectrum of action
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Citrobacter diversus, Corynebacterium diphtheriae, Erysopelothrix rhusiopathiae, E. coli, Klebsiella spp., Moraxella catarrhalis, Neisseria spp., Proteus mirabilis, Salmonella spp.

Indication
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Respiratory, urinary tract, skin, soft tissue and wound infections caused by gram-positive pathogens (except listeria), gonorrhoea.

Dosage and method of use
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Adults/children > 1 year: 2-3 g/day in 2-3 ED i.v.
Children after the 1st month of life: 25-50 mg/kg bw/day.
children after the 1st year of life: 50-100 mg/kg bw/day.

Preparations
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Cefazolin, Elzogram

Note(s)
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Cephalosporin is the most effective against staphylococci.

Literature
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Stryjewski ME et al (2007) Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia. Clin Infect Dis 44: 190-196