Cd81

Author:Prof. Dr. med. Peter Altmeyer

Last updated on: 27.01.2022

Synonym(s)

Target of antiproliferative antibodies (TAPA-1)

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DefinitionThis section has been translated automatically.

Marker for: Lymphocytes

Structure: 26 kDa

Note: CD81 associates with CD19 and CD21 to form the B cell co-receptor.

CD81 acts together with CLDN1 as a co-receptor for hepatitis C virus (HCV) in hepatocytes. It forms a CLDN1-CD81 receptor complex, which is essential for HCV entry into the host cell. Thus, these proteins occupy an important role in the biology of liver disease and in their function as cell entry receptors for HCV-one of the most common causes of hepatocellular carcinoma (Zeisel MB et al. 2019).

(see also below) Cluster of differentiation

Authors

Last updated on: 27.01.2022

Author: Prof. Dr. med. Peter Altmeyer