Cd45

Acronym for"cluster of differentiation 45". CD45 marks all leukocytes: lymphocytes, eosinophils, monocytes, basophils, neutrophils (in descending expression density), metastases of neuroendocrine tumors. CD45 is considered the most important marker for differentiating a lymphoma from a non-lymphoid tumor.

Structure: integral membrane protein (5 isoforms 180-220 kDa); clone: 2B11; PD7/26

Application: FACS, IHC (P) (G), IF.

The CD45-encoding gene, the PTPRC gene (PTPRC is the acronym for "Protein Tyrosine Phosphatase Receptor Type C") is located on chromosome 1q31.3-q32.1. CD45 belongs to the protein tyrosine phosphatase (PTP) family. PTPs are known signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. CD45 is expressed on all hematopoietic cells except mature erythrocytes and their immediate progenitors. However, it is not found on other differentiated tissues; therefore, it can be used as an antigenic marker to identify undifferentiated hematopoietic tumors.

1. Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer Publishing House Berlin-Heidelberg p. 27.