Cd43

Acronym for cluster of differentiation 43. CD43 is a marker for T cells (no B cells, except for immature activated B cells); furthermore myeloid cells (granulocytes, monocytes).

Structure: membrane glycoprotein (95-135 kDa); clone: DF-T1, MT1

Application: FACS, IHC (P) (G), IF

The binding of CD40 and CD154 to T cells enables the growth and differentiation of B cells. CD43 is not a specific T-cell marker, but the coexpression of CD43/CD5 with CD20 is considered an important indication of the presence of low-malignant B-cell lymphoma (e.g. B-CLL).

1. Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer publishing house Berlin-Heidelberg p. 26-33.