Cd40

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 15.03.2022

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Synonym(s)

CD154 Ligand

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DefinitionThis section has been translated automatically.

Markers for: B cells, interdigitating cells, fibroblasts, macrophages, follicular dendritic cells

Structure: Phosphoglycoprotein (44-48 kDa)

Note: Binding of CD40 and CD154 to T-cells enables growth and differentiation of B-cells.

Application: FACS, IHC (P) (G), IF

(see below) Cluster of differentiation

General informationThis section has been translated automatically.

CD40 also named "tumor necrosis factor receptor superfamily 5, or TNFRSF 5" is a surface protein of the tumor necrosis factor receptor superfamily.

CD40 is a costimulator in B cells, dendritic cells, and some tumors.

CD40 is the receptor of the ligand TNFSF5 (CD40L).

CD40 is involved in the activation of ERK in macrophages and B cells, whereupon antibodies are increasingly secreted in B cells. The protein is present in glycosylated form.

LiteratureThis section has been translated automatically.

  1. Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer publishing house Berlin-Heidelberg p. 26-33.

Authors

Last updated on: 15.03.2022

Author: Prof. Dr. med. Peter Altmeyer