Cd40

Markers for: B cells, interdigitating cells, fibroblasts, macrophages, follicular dendritic cells

Structure: Phosphoglycoprotein (44-48 kDa)

Note: Binding of CD40 and CD154 to T-cells enables growth and differentiation of B-cells.

Application: FACS, IHC (P) (G), IF

(see below) Cluster of differentiation

CD40 also named "tumor necrosis factor receptor superfamily 5, or TNFRSF 5" is a surface protein of the tumor necrosis factor receptor superfamily.

CD40 is a costimulator in B cells, dendritic cells, and some tumors.

CD40 is the receptor of the ligand TNFSF5 (CD40L).

CD40 is involved in the activation of ERK in macrophages and B cells, whereupon antibodies are increasingly secreted in B cells. The protein is present in glycosylated form.

1. Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer publishing house Berlin-Heidelberg p. 26-33.