Cd30

Acronym for Cluster of differentiation 30.

CD30 is a marker for: activated T and B cells, Hodgkin and Reed-Sternberg cells, anaplastic large lymphoma cells, decidua cells (in endometriosis) CD30 is rarely found in nevus cells, but more frequently in dysplastic melanocytic nevi and malignant melanomas (but has no diagnostic relevance).

Overexpression of CD30 in MF may indicate transformation and a worse prognosis (Fauconneau A et al. 2015).

Structure: Transmembrane cytokine receptor (120 kDa) from the group of the tumor necrosis factor receptor family.

Note: CD30 (Ki-1 antigen) belongs to the tumor necrosis factors. The antigen plays a role in regulating the function, differentiation and/or proliferation of normal lymphoid cells. It is characterized by a punctiform staining of the cell membrane. Occurs in numerous cutaneous lymphomas (LyP, ALCL, etc.). CD30 is rarely expressed in myelosarcoma or nevus cell navi, but more often in dysplastic nevi and melanomas (without prognostic relevance).

Application: FACS, IHC (P) (G), IF

1. Fauconneau A et al (2015) Assessment of diagnostic criteria between primary cutaneous anaplastic large-cell lymphoma and CD30-rich transformed mycosis fungoides; a study of 66 cases.
   Br J Dermatol 172 :1547-54.
   
2. Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer publishing house Berlin-Heidelberg p. 26-33.