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Cd15

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Lewis X (Le x)

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DefinitionThis section has been translated automatically.

Acronym for Cluster of differentiation 15th CD15 is a marker for: granulocytes, monocytes, myeloid cells, dendritic reticulum cells, Hodgkin and Sternberg-Reed cells and carcinomas in the epithelia (sebaceous glands, Scheweiß glands).

Structure: Carbohydrate antigen

Application: FACS, IHC (P) (G), IF

General informationThis section has been translated automatically.

CD15 serves as a ligand for selectins and is involved in cell adhesion through a direct Lewis X-Lewis X interaction. CD15 is expressed on leukemic cells of myelo-monocytic origin. Less frequently, cells of ALL are marked. CD15 is not suitable for differentiating Hodgkin's disease from myelosarcoma.

LiteratureThis section has been translated automatically.

  1. Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer publishing house Berlin-Heidelberg p. 26-33.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer