Synonym(s)
Lewis X (Le x)
DefinitionThis section has been translated automatically.
Acronym for Cluster of differentiation 15th CD15 is a marker for: granulocytes, monocytes, myeloid cells, dendritic reticulum cells, Hodgkin and Sternberg-Reed cells and carcinomas in the epithelia (sebaceous glands, Scheweiß glands).
Structure: Carbohydrate antigen
Application: FACS, IHC (P) (G), IF
General informationThis section has been translated automatically.
CD15 serves as a ligand for selectins and is involved in cell adhesion through a direct Lewis X-Lewis X interaction. CD15 is expressed on leukemic cells of myelo-monocytic origin. Less frequently, cells of ALL are marked. CD15 is not suitable for differentiating Hodgkin's disease from myelosarcoma.
LiteratureThis section has been translated automatically.
- Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer publishing house Berlin-Heidelberg p. 26-33.
Prof. Dr. med. Peter Altmeyer