Cd126

CD126(the acronym CD stands for "cluster of differentiation" and refers to groups of cellular surface features that have been ordered according to biochemical or functional criteria. The CD classification enables a comprehensible transparency in immunohistological and immunological diagnostics) designates the interleukin-6 receptor alpha chain (see below Interleukin-6).

This protein is
expressedby neoplastic but not by
mature plasma cells. It plays a central role in the pathogenesis of myeloma. CD126 induces proliferation and inhibits apoptosis of neoplastic plasma cells. In this respect, its blocking is the target of therapeutic efforts.

1. Rawstron AC et al (2000) The interleukin-6 receptor alpha-chain (CD126) is expressed by neoplastic but not normal plasma cells. Blood 96:3880-3886.